![]() Folate in its tetrahydro form is a transporter of one-carbon fragments, which it can carry at any of three oxidation levels: methanol, formaldehyde, or formic acid. ![]() Deficiency of either folate or cobalamin (vitamin B 12) leads to macrocytic anemia with or without other cytopenias as a result of megaloblastic hematopoiesis, a manifestation of defective DNA synthesis.
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